
A new breakthrough in the fight against dementia. Taiwan has approved a targeted therapy aimed at slowing cognitive decline in patients with early-stage symptoms. The treatment uses anti-amyloid targeted therapy to remove harmful proteins in the brain before they can alter its structure. Right now, it’s only approved for mild dementia patients, while clinical trials are still needed for those in moderate to severe stages. Let’s hear from a doctor.
Hu Chaur-jong
Taipei Medical University College of Medicine
People with mild dementia, or mild cognitive impairment make up more than 15% of the population aged 65 and up. With early intervention and diagnosis, we can prevent the condition from progressing to moderate or severe dementia. That would significantly reduce the burden of care.
Hsu Jung-lung
Taiwan Dementia Society
Inside the brain there are two proteins, amyloid-beta and tau proteins that act like two villains. They are bad proteins, and they can damage nerve cells and impairing brain function. So this new targeted drug can take these protein villains away to slow down progression of the disease.
The total number of dementia patients is expected to reach 680,000 in 15 years, making for a prevalence rate of 10%. Doctors remind the general public that dementia is a medical condition that does not necessarily develop with age. Signs to watch out for include memory loss, declining logic and judgment, and trouble with language. They may also include sudden mood changes or personality shifts, withdrawal from society, poor task execution and confusion regarding time and place. Misplacing objects frequently can also be an early indicator. Experts say that the sooner you detect these signs and seek medical attention for treatment, the better.
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#dementia #medicine #protein #aging #eldercare
台灣失智症人口逐年上升,預估再過15年後,將逼近68萬人,盛行率高達10%,為了降低失智症的發生率,又有新的治療法通過核准,利用"抗類澱粉蛋白標靶治療",去除腦中不好的蛋白,避免改變腦部結構,但目前只適用輕度病人,對中、重度失智症的患者,還要進行臨床實驗。
[[台北醫學大學醫學院院長 胡朝榮]]
“極輕度或者是MCI (輕度認知功能障礙)的這一群人,大概佔了我們65歲以上的族群超過百分之15%,我們可以早點介入,早點診斷,可以把這個病人,擋在這個MCI這個階段,那他就不會往這個中度、重度走,說不定我們就可以減少很多,這個照顧上的負擔”
[[台灣臨床失智症學會理事長 徐榮隆]]
“在腦子裡面有這些毒性的蛋白,比如說像是類澱粉蛋白,Tau蛋白,就好像是兩個壞蛋,它們是一個不好的蛋白質,那麼這些不好的蛋白質,影響到我們的神經細胞,讓我們失去功能,所以我們這個新的標靶的藥物,就是把其中一個壞蛋把它清乾淨,讓我們的疾病的進展就會減慢”
醫生強調,失智症和老化不同,如果出現記憶力、邏輯退化,判斷力減弱,或是語言能力退化,情緒個性改變,對社交退縮,執行力變差,對時間、空間混亂,找不到東西等十大警訊,就要小心可能是失智症,最好及早就醫,早期預防。
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